Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study.

Nature communications - 21 Jun 2024

Dunca Diana, Chopade Sandesh, Gordillo-Marañón María, Hingorani Aroon D, Kuchenbaecker Karoline, Finan Chris, Schmidt Amand F

Abstract excerpt

CETP inhibitors are a class of lipid-lowering drugs in development for treatment of coronary heart disease (CHD). Genetic studies in East Asian ancestry have interpreted the lack of CETP signal with low-density lipoprotein cholesterol (LDL-C) and lack of drug target Mendelian randomization (MR) effect on CHD as evidence that CETP inhibitors might not be effective in East Asian participants. Capitalizing on recent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticholesteremic Agents
Share to Blood Pressure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cardiovascular Diseases

Share to Cholesterol Ester Transfer Proteins

Share to Cholesterol, HDL

Share to Cholesterol, LDL

Share to Coronary Disease

Share to East Asian People

Source

Open in PubMed Open full text

Identifiers

PMID: 38906890
DOI: 10.1038/s41467-024-49109-z
PMCID: PMC11192935

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparing the effects of CETP in East Asian and European ancestries: a Mendelian randomization study.PMID 38906890Read ↗

Comparing the effect profile of CETP in individuals of East Asian and European ancestriesSemantic proximity Read ↗

Comparing the effect profile of cholesteryl ester transfer protein (CETP) in individuals of East Asian and European ancestriesSemantic proximity Read ↗

Lipids, Blood Pressure, and Diabetes Mellitus on Risk of Cardiovascular Diseases in East Asians: A Mendelian Randomization StudySemantic proximity Read ↗

Cholesteryl ester transfer protein (CETP) as a drug target for cardiovascular diseaseSemantic proximity Read ↗

Effects of genetically proxied lipid-lowering drugs on acute myocardial infarction: a drug-target mendelian randomization study.Semantic proximity Read ↗

Evaluating the role of non-alcoholic fatty liver disease in cardiovascular diseases and type 2 diabetes: a Mendelian randomization study in Europeans and East Asians.Semantic proximity Read ↗

Cholesteryl Ester Transfer Protein as a Drug Target for Cardiovascular DiseaseSemantic proximity Read ↗

Cholesteryl Ester Transfer Protein as a Drug Target for Cardiovascular DiseaseSemantic proximity Read ↗

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisationSemantic proximity Read ↗

Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition.Semantic proximity Read ↗

Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms.Semantic proximity Read ↗

Effects of ACLY Inhibition on Body Weight Distribution: A Drug Target Mendelian Randomization Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.