Article
Increased sensitivity of malaria parasites to common antimalaria drugs after the introduction of artemether-lumefantrine: Implication of policy change and implementation of more effective drugs in fight against malaria.
PloS one - 1 Jan 2024
Okore Winnie, Ouma Collins, Okoth Raphael O, Yeda Redemptah, Ingasia Luicer O, Mwakio Edwin W, Ochora Douglas O, Wakoli Duncan M, Amwoma Joseph G, Chemwor Gladys C, Juma Jackline A, Okudo Charles O, Cheruiyot Agnes C, Opot Benjamin H, Juma Dennis, Egbo Timothy E, Andagalu Ben, Roth Amanda, Kamau Edwin, Akala Hoseah M
Abstract excerpt
Single nucleotide polymorphisms (SNPs) in the Plasmodium falciparum multi-drug resistance protein 1 (Pfmrp1) gene have previously been reported to confer resistance to Artemisinin-based Combination Therapies (ACTs) in Southeast Asia. A total of 300 samples collected from six sites between 2008 and 2019 under an ongoing malaria drug sensitivity patterns in Kenya study were evaluated for the presence of SNPs at...
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