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Article

Changes in susceptibility of Plasmodium falciparum to antimalarial drugs in Uganda over time: 2019-2024.

Nature communications - 9 Aug 2025

Okitwi Martin, Orena Stephen, Tumwebaze Patrick K, Katairo Thomas, Taremwa Yoweri, Byaruhanga Oswald, Tukwasibwe Stephen, Nsobya Samuel L, Legac Jennifer, Bailey Jeffrey A, Cooper Roland A, Conrad Melissa D, Rosenthal Philip J

Abstract excerpt

The treatment and control of malaria in Africa is challenged by drug resistance. We characterized ex vivo susceptibilities to nine drugs of isolates collected from individuals presenting with uncomplicated falciparum malaria in eastern (2019-2024) and northern (2021-2024) Uganda and performed deep sequencing, with analysis of 80 Plasmodium falciparum genes, to evaluate associations between susceptibilities and...

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Identifiers

PMID: 40783405
DOI: 10.1038/s41467-025-62810-x
PMCID: PMC12335539

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