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Systematic characterization of pyroptosis-related gene patterns identifies potential prognostic inflammatory phenotypes in sepsis.

Functional & integrative genomics - 13 Jun 2026

Wang Mingchun, Xiao Yu, Zhong Duming, Cao Lianghai, Ngan Chansokhon, Lei Haiyun

Abstract excerpt

Sepsis is a life-threatening syndrome driven by a dysregulated host response to infection, yet reliable prognostic biomarkers remain limited. Pyroptosis has emerged as an important contributor to immune dysregulation in sepsis. Here, we systematically characterized pyroptosis-related gene (PRG) patterns using public transcriptomic cohorts (GSE65682). Consensus clustering identified two distinct molecular...

Topics

Humans
Pyroptosis
Sepsis
Prognosis
Phenotype
Inflammation
Transcriptome

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 42286183
DOI: 10.1007/s10142-026-01913-0

Genes

CTLA4
CX3CR1
CXCL8
DEFA4
TIGIT
TNFAIP3
TUBG2
WFDC1
ZBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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