Article
Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis.
The pharmacogenomics journal - 1 Jun 2013
Man M, Close S L, Shaw A D, Bernard G R, Douglas I S, Kaner R J, Payen D, Vincent J-L, Fossceco S, Janes J M, Leishman A G, O'Brien L, Williams M D, Garcia J G N
Abstract excerpt
Management of severe sepsis, an acute illness with high morbidity and mortality, suffers from the lack of effective biomarkers and largely empirical predictions of disease progression and therapeutic responses. We conducted a genome-wide association study using a large randomized clinical trial cohort to discover genetic biomarkers of response to therapy and prognosis utilizing novel approaches, including...
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