Genetic change may be caused by interference with protein-protein interactions.

doi:10.1016/0027-5107(85)90116-2

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Article

Genetic change may be caused by interference with protein-protein interactions.

Mutation research - 1 Jan 2000

Zimmermann F K, Gröschel-Stewart U, Scheel I, Resnick M A

Abstract excerpt

Several aprotic polar solvents were shown to induce mitotic aneuploidy in yeast: diethyl ketone, gamma-valerolactone, pyridine, pivalinic acid nitrile, phenylacetonitrile and fumaric acid dinitrile. Only fumaric acid dinitrile also strongly induced other types of genetic effects including mitotic...

Topics

Aneuploidy
Gene Conversion
Mitosis
Mutation
Protein Binding
Saccharomyces cerevisiae
Solvents
Spindle Apparatus
Structure-Activity Relationship
Tubulin

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