Article
In-vitro testing and the carcinogenic potential of several nitrosated indole compounds.
Cell biology and toxicology - 1 Oct 1991
Tiedink H G, de Haan L H, Jongen W M, Koeman J H
Abstract excerpt
4-chloro-methoxyindole is a naturally occurring compound in Vicia faba which can easily react with nitrite to form a N-nitroso compound. In this in vitro study, the potential genotoxic effects of nitrosated 4-chloro-6-methoxyindole and its structural analogue 4-chloroindole were evaluated for the first time by using both Salmonella and Chinese hamster V79 cells. Additionally, the inhibition of gap junctional...
Topics
- Animals
- Carcinogenicity Tests
- Carcinogens
- Cell Communication
- Cell Line
- Cricetinae
- Cricetulus
- Indoles
- Mutagenicity Tests
- Mutagens
- Mutation
- Nitrosation