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Article

Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer.

Cancer letters - 1 Dec 2021

Hanada Keita, Kawada Kenji, Nishikawa Gen, Toda Kosuke, Maekawa Hisatsugu, Nishikawa Yasuyo, Masui Hideyuki, Hirata Wataru, Okamoto Michio, Kiyasu Yoshiyuki, Honma Shusaku, Ogawa Ryotaro, Mizuno Rei, Itatani Yoshiro, Miyoshi Hiroyuki, Sasazuki Takehiko, Shirasawa Senji, Taketo M Mark, Obama Kazutaka, Sakai Yoshiharu

Abstract excerpt

Mutations of KRAS gene are found in various types of cancer, including colorectal cancer (CRC). Despite intense efforts, no pharmacological approaches are expected to be effective against KRAS-mutant cancers. Macropinocytosis is an evolutionarily conserved actin-dependent endocytic process that internalizes extracellular fluids into large vesicles called macropinosomes. Recent studies have revealed...

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PMID: 34543685
DOI: 10.1016/j.canlet.2021.09.023

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Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer.PMID 34543685Read ↗

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