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Mutational landscape and risk estimates of DDR genes in Chinese ovarian cancer patients.

Journal of ovarian research - 10 Dec 2025

Zhang Cuiyun, Wei Bing, Xue Xia, Xia Qingxin, Wang Yi, Guo Lanwei, Wang Tingjie, Wang Li, Deng Junli, Guan Yuping, Wang Xiaoyan, Feng Lu, Wu Rui, Hu Ziqing, Kok Klaas, van den Berg Anke, Guo Yongjun, Li Jun

Abstract excerpt

BACKGROUND: Pathogenic/likely pathogenic variants (P/LPVs) in DNA damage response (DDR) genes are known ovarian cancer (OC) risk factors, but gene-specific risk estimates in Han Chinese remain unclear. OBJECTIVE: To accurately assess the risk associated with DDR genes in the Han Chinese population to facilitate personalized risk management and enhance clinical decision-making. METHODS: We performed...

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Identifiers

PMID: 41373018
DOI: 10.1186/s13048-025-01925-7
PMCID: PMC12879432

Genes

BRCA1
BRCA2
MSH2
RAD51C
RAD51D

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