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Potentially Functional Variants in FCER1A and PLCG2, Two B Cell-Related Immune Genes Predict the Survival of Chinese Gastric Cancer Patients.

Molecular carcinogenesis - 1 Aug 2026

Zeng Guang, Lu Guoqiang, Hu Beiping, Xu Midie, Li Guanlin, Wang Mengyun, Qiu Lixin, Cheng Lei, Zhang Ruoxin, Xu Wanghong, Liu Xiaowen, Jin Guangfu, Liu Hongliang, Wei Qingyi

Abstract excerpt

B cells are integral components of the tumor microenvironment (TME) and influence the progression, prognosis, and immunotherapy response of gastric cancer (GC). However, the prognostic relevance of germline variants in B cell-related immune genes remains undefined. We performed a two-stage genome-wide association analysis to identify single-nucleotide polymorphisms (SNPs) in B cell-related immune genes associated...

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Identifiers

PMID: 42138601
DOI: 10.1002/mc.70125
PMCID: PMC13372433

Genes

GC
FCER1A
PLCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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