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A BRCA1 Splice Site Variant Responsible for Familial Ovarian Cancer in a Han-Chinese Family.

Current medical science - 1 Jun 2022

Hu Peng-Zhi, Chen Xiang-Yu, Xiong Wei, Yang Zhi-Jian, Li Xiao-Rong, Deng Wen-Zhi, Gong Li-Na, Deng Hao, Yuan La-Mei

Abstract excerpt

OBJECTIVE: Ovarian cancer (OC) is one of the most common and most lethal gynecological malignancies. OC has an age-dependent incidence and occurs more commonly in females older than 50 years old. Most OC patients are diagnosed at an advanced stage and have a poor prognosis. Germline mutations in the BRCA1 DNA repair associated gene (BRCA1) and the BRCA2 DNA repair associated gene (BRCA2) account for 20%-25% of...

Topics

Adenocarcinoma
BRCA1 Protein
Carcinoma, Ovarian Epithelial
China
Female
Genetic Predisposition to Disease
Humans
Middle Aged
Ovarian Neoplasms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35290602
DOI: 10.1007/s11596-022-2527-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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