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Article

An integrated inspection of the somatic mutations in a lung squamous cell carcinoma using next-generation sequencing.

PloS one - 1 Jan 2013

Stead Lucy F, Egan Philip, Devery Aoife, Conway Caroline, Daly Catherine, Berri Stefano, Wood Henry, Belvedere Ornella, Papagiannopoulos Kostas, Ryan Anderson, Rabbitts Pamela

Abstract excerpt

Squamous cell carcinoma (SCC) of the lung kills over 350,000 people annually worldwide, and is the main lung cancer histotype with no targeted treatments. High-coverage whole-genome sequencing of the other main subtypes, small-cell and adenocarcinoma, gave insights into carcinogenic mechanisms and disease etiology. The genomic complexity within the lung SCC subtype, as revealed by The Cancer Genome Atlas, means...

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Topics

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Share to Carcinoma, Squamous Cell
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Gene Expression Regulation, Neoplastic

Share to High-Throughput Nucleotide Sequencing

Share to Lung Neoplasms

Share to Neoplasm Proteins

Share to Transcription, Genetic

Source

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Identifiers

PMID: 24244370
DOI: 10.1371/journal.pone.0078823
PMCID: PMC3823931

Genes

BRCA1
BRCA2
PARP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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