Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mendelian randomization evidence for the causal effect of mental well-being on healthy aging.

Nature human behaviour - 1 Sept 2024

Ye Chao-Jie, Liu Dong, Chen Ming-Ling, Kong Li-Jie, Dou Chun, Wang Yi-Ying, Xu Min, Xu Yu, Li Mian, Zhao Zhi-Yun, Zheng Rui-Zhi, Zheng Jie, Lu Jie-Li, Chen Yu-Hong, Ning Guang, Wang Wei-Qing, Bi Yu-Fang, Wang Tian-Ge

Abstract excerpt

Mental well-being relates to multitudinous lifestyle behaviours and morbidities and underpins healthy aging. Thus far, causal evidence on whether and in what pattern mental well-being impacts healthy aging and the underlying mediating pathways is unknown. Applying genetic instruments of the well-being spectrum and its four dimensions including life satisfaction, positive affect, neuroticism and depressive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Health Status

Share to Longevity

Share to Mendelian Randomization Analysis

Share to Mental Health

Share to Neuroticism

Share to Resilience, Psychological

Source

Identifiers

PMID: 38886532
DOI: 10.1038/s41562-024-01905-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mendelian randomization evidence for the causal effect of mental well-being on healthy aging.PMID 38886532Read ↗

Genetic association and potential mediators between subjective well-being and cardiovascular events: A bidirectional two-sample, two-step Mendelian randomization study.Semantic proximity Read ↗

Testing the causal effects between subjective wellbeing and physical health using Mendelian randomisationSemantic proximity Read ↗

Bidirectional causal associations between aging and major mental disorders: A population-based study using the two-sample mendelian randomization method from the UK biobank (AM-SRNMA 002).Semantic proximity Read ↗

Life-course influence of birthweight and subsequent pathways on healthy aging: a Mendelian randomization study.Semantic proximity Read ↗

Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation studySemantic proximity Read ↗

Genetic Risks for Chronic Conditions: Implications for Long-term Wellbeing.Semantic proximity Read ↗

Psychological resources confer greatest protection against late-life depression in genetically vulnerable adultsSemantic proximity Read ↗

Physical Resilience May Offset Mortality Risks Associated With Genetic Predisposition to Shorter Survival: A Population-based Cohort Study.Semantic proximity Read ↗

Causal association of modifiable factors with cardiometabolic multimorbidity: an exposome-wide Mendelian randomization investigation.Semantic proximity Read ↗

Genetically Proxied Telomere Length but Not Epigenetic Aging Acceleration Causally Influences Healthspan: A Mendelian Randomization StudySemantic proximity Read ↗

Genetic Evidence for Causal Effects of Socioeconomic, Lifestyle, and Cardiometabolic Factors on Epigenetic-Age Acceleration.Semantic proximity Read ↗

The healthy aging phenotype in older people in ManizalesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.