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Article

Causal association of modifiable factors with cardiometabolic multimorbidity: an exposome-wide Mendelian randomization investigation.

Cardiovascular diabetology - 6 Jun 2025

Li Dun, Lin Jing, Yang Hongxi, Zhou Lihui, Li Yujian, Xu Zhe, Sun Li, Zhang Xinyu, Xu Weili, Wang Yaogang

Abstract excerpt

BACKGROUND: Cardiometabolic multimorbidity (CMM), characterized by the co-existence of two or more cardiometabolic diseases (CMDs) including type 2 diabetes (T2D), coronary artery disease (CAD), and stroke, persists as a global health challenge. However, the causal associations of modifiable factors with CMDs and CMM remains to be systematically investigated. METHODS: In this study, a three-stage design Mendelian...

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Identifiers

PMID: 40481456
DOI: 10.1186/s12933-025-02790-w
PMCID: PMC12143095

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CAD

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