Article
C. elegans LIN-66 mediates EIF-3/eIF3-dependent protein translation via a cold-shock domain.
Life science alliance - 1 Sept 2024
Blazie Stephen M, Fortunati Daniel, Zhao Yan, Jin Yishi
Abstract excerpt
Protein translation initiation is a conserved process involving many proteins acting in concert. The 13 subunit eukaryotic initiation factor 3 (eIF3) complex is essential for assembly of the pre-initiation complex that scans mRNA and positions ribosome at the initiation codon. We previously reported that a gain-of-function (gf) mutation affecting the G subunit of the Caenorhabditis elegans eIF3 complex,...
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