Article
TGFbeta family members are key mediators in the induction of myofibroblast phenotype of human adipose tissue progenitor cells by macrophages.
PloS one - 1 Jan 2012
Bourlier Virginie, Sengenès Coralie, Zakaroff-Girard Alexia, Decaunes Pauline, Wdziekonski Brigitte, Galitzky Jean, Villageois Phi, Esteve David, Chiotasso Patrick, Dani Christian, Bouloumié Anne
Abstract excerpt
OBJECTIVE: The present study was undertaken to characterize the remodeling phenotype of human adipose tissue (AT) macrophages (ATM) and to analyze their paracrine effects on AT progenitor cells. RESEARCH DESIGN AND METHODS: The phenotype of ATM, immunoselected from subcutaneous (Sc) AT originating from subjects with wide range of body mass index and from paired biopsies of Sc and omental (Om) AT from obese...
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