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Article

Human adipose mesenchymal stem cells modulate myeloid cells toward an anti-inflammatory and reparative phenotype: role of IL-6 and PGE2.

Stem cell research & therapy - 2 Nov 2020

Ortiz-Virumbrales Maitane, Menta Ramón, Pérez Laura M, Lucchesi Ornella, Mancheño-Corvo Pablo, Avivar-Valderas Álvaro, Palacios Itziar, Herrero-Mendez Angel, Dalemans Wilfried, de la Rosa Olga, Lombardo Eleuterio

Abstract excerpt

BACKGROUND: Mesenchymal stem cells (MSCs) activate the endogenous immune regulatory system, inducing a therapeutic effect in recipients. MSCs have demonstrated the ability to modulate the differentiation of myeloid cells toward a phagocytic and anti-inflammatory profile. Allogeneic, adipose-derived MSCs (ASCs) have been investigated for the management of complex perianal fistula, with darvadstrocel being the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33138862
DOI: 10.1186/s13287-020-01975-2
PMCID: PMC7607855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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