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Article

Evaluation of Droplet Digital PCR for the Detection of BRAF V600E in Fine-Needle Aspiration Specimens of Thyroid Nodules.

Annals of laboratory medicine - 1 Nov 2024

Min Young Kyu, Kim Jae Kyung, Park Kyung Sun, Kim Jong-Won

Abstract excerpt

Background: Droplet digital (dd)PCR is a new-generation PCR technique with high precision and sensitivity; however, the positive and negative droplets are not always effectively separated because of the "rain" phenomenon. We aimed to develop a practical optimization and evaluation process for the ddPCR assay and to apply it to the detection of BRAF V600E in fine-needle aspiration (FNA) specimens of thyroid...

Topics

Proto-Oncogene Proteins B-raf
Humans
Biopsy, Fine-Needle
Thyroid Nodule
Polymerase Chain Reaction
Thyroid Neoplasms
Sensitivity and Specificity
Thyroid Cancer, Papillary
Mutation
Limit of Detection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Female

Adult

Male

Carcinoma, Papillary

Prospective Studies

Aged

DNA Primers

Source

Open in PubMed Open full text

Identifiers

PMID: 38872331
DOI: 10.3343/alm.2023.0405
PMCID: PMC11375207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-38872331-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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