Article
Digital droplet PCR TERT promoter mutational screening in fine needle aspiration cytology of thyroid lesions: A highly specific technique for pre-operative identification of high-risk cases.
Diagnostic cytopathology - 1 Jun 2023
Hysek Martin, Hellgren L Samuel, Stenman Adam, Darai-Ramqvist Eva, Ljung Elin, Schliemann Igor, Condello Vincenzo, Larsson Catharina, Zedenius Jan, Jatta Kenbugul, Juhlin C Christofer
Abstract excerpt
BACKGROUND: Despite the advent of comprehensive molecular testing in surgical pathology, most centers still rely on the morphological assessment of fine-needle aspiration cytology (FNAC) to triage patients with thyroid nodules for surgery. Subsets of patients could benefit from the inclusion of molecular testing to increase the diagnostic and/or prognostic properties of the cytology analysis, including the...
Topics
- Humans
- Biopsy, Fine-Needle
- Prospective Studies
- Proto-Oncogene Proteins B-raf
- Thyroid Neoplasms
- Thyroid Nodule
- Mutation
- Polymerase Chain Reaction
- Telomerase