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Article

Detection of BRAFV600E by digital PCR on fine-needle aspirate enables rapid initiation of dabrafenib and trametinib in unresectable anaplastic thyroid carcinoma.

European journal of endocrinology - 1 Sept 2022

Buffet Camille, Allard Lucie, Guillerm Erell, Ghander Cécile, Mathy Elise, Lussey-Lepoutre Charlotte, Julien Nicolas, Touma Eliane, Quilhot Pauline, Godiris-Petit Gaelle, Lacorte Jean-Marc, Leenhardt Laurence, Denis Jérôme Alexandre

Abstract excerpt

Introduction: Recently, targeted therapies using BRAFV600E and MEK inhibitors (dabrafenib and trametinib, respectively) have been recommended in BRAF-mutated anaplastic thyroid carcinoma (ATC). Considering the fast development of ATC, droplet digital PCR (ddPCR) performed on fine-needle aspirate (FNA), which is a rapid, reliable, and low-cost method, appears interesting for the detection of BRAFV600E mutation in...

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PMID: 35900324
DOI: 10.1530/EJE-22-0366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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