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Comparative analysis of IHC, AMRS-PCR, and ddPCR for BRAF V600E mutation detection in papillary thyroid carcinoma.

Cancer treatment and research communications - 1 Jan 2026

Chang Chen, Fang Guodong, Lei Jianyuan, Liu Lele, Wang Guorong, Li Wensheng

Abstract excerpt

BACKGROUND: The BRAF V600E mutation is the most frequent driver alteration in papillary thyroid carcinoma (PTC) and plays an important role in diagnosis, risk stratification, and treatment planning. Commonly used detection methods include immunohistochemistry (IHC), amplification-refractory mutation system PCR (AMRS-PCR), and droplet digital PCR (ddPCR). However, their relative performance and their ability to...

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Source

Identifiers

PMID: 41496267
DOI: 10.1016/j.ctarc.2025.101085

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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