Article
Identification of RAD17 as a candidate cancer predisposition gene in families with histories of pancreatic and breast cancers.
BMC cancer - 13 Jun 2024
Joris Sofie, Giron Philippe, Olsen Catharina, Seneca Sara, Gheldof Alexander, Staessens Shula, Shahi Rajendra Bahadur, De Brakeleer Sylvia, Teugels Erik, De Grève Jacques, Hes Frederik J
Abstract excerpt
BACKGROUND: Among the 10% of pancreatic cancers that occur in a familial context, around a third carry a pathogenic variant in a cancer predisposition gene. Genetic studies of pancreatic cancer predisposition are limited by high mortality rates amongst index patients and other affected family members. The genetic risk for pancreatic cancer is often shared with breast cancer susceptibility genes, most notably...
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