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Article

Germline DNA Sequencing Reveals Novel Mutations Predictive of Overall Survival in a Cohort of Patients with Pancreatic Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2020

Goldstein Jennifer B, Zhao Li, Wang Xuemei, Ghelman Yael, Overman Michael J, Javle Milind M, Shroff Rachna T, Varadhachary Gauri R, Wolff Robert A, McAllister Florencia, Futreal Andrew, Fogelman David R

Abstract excerpt

PURPOSE: Family history of BRCA-related tumors may correlate with response to chemotherapy and overall survival (OS) in pancreatic cancer. The frequency of germline mutations has been reported in patients predominantly under the age of 60 or with strong family history. We examine the incidence of deleterious germline mutations and compare the chemotherapy responses and OS in an unselected group of patients with...

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PMID: 31871297
DOI: 10.1158/1078-0432.CCR-19-0224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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