History of tuberculosis disease is associated with genetic regulatory variation in Peruvians.

doi:10.1371/journal.pgen.1011313

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Article

History of tuberculosis disease is associated with genetic regulatory variation in Peruvians.

PLoS genetics - 1 Jun 2024

Nieto-Caballero Victor E, Reijneveld Josephine F, Ruvalcaba Angel, Innocenzi Gabriel, Abeydeera Nalin, Asgari Samira, Lopez Kattya, Iwany Sarah K, Luo Yang, Nathan Aparna, Fernandez-Salinas Daniela, Chiñas Marcos, Huang Chuan-Chin, Zhang Zibiao, León Segundo R, Calderon Roger I, Lecca Leonid, Budzik Jonathan M, Murray Megan, Van Rhijn Ildiko, Raychaudhuri Soumya, Moody D Branch, Suliman Sara, Gutierrez-Arcelus Maria

Abstract excerpt

A quarter of humanity is estimated to have been exposed to Mycobacterium tuberculosis (Mtb) with a 5-10% risk of developing tuberculosis (TB) disease. Variability in responses to Mtb infection could be due to host or pathogen heterogeneity. Here, we focused on host genetic variation in a Peruvian population and its associations with gene regulation in monocyte-derived macrophages and dendritic cells (DCs). We...

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PMID: 38870230
DOI: 10.1371/journal.pgen.1011313
PMCID: PMC11208071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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