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Higher native Peruvian genetic ancestry proportion is associated with tuberculosis progression risk

27 Jun 2022

Abstract excerpt

We investigated whether ancestry-specific genetic factors affect tuberculosis (TB) progression risk in a cohort of admixed Peruvians. We genotyped 2,105 patients with TB and 1,320 household contacts (HHCs) who were infected with Mycobacterium tuberculosis (M. tb) but did not develop TB and inferred each individual’s proportion of native Peruvian genetic ancestry. Our HHC study design and our data on potential...

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PMID: 35873671
DOI: 10.1016/j.xgen.2022.100151

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