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Article

Dissecting the association between psychiatric disorders and neurological proteins: a genetic correlation and two-sample bidirectional Mendelian randomization study.

Acta neuropsychiatrica - 1 Dec 2022

Huang Huimei, Cheng Shiqiang, Li Chun'e, Cheng Bolun, Liu Li, Yang Xuena, Meng Peilin, Yao Yao, Pan Chuyu, Zhang Jingxi, Zhang Huijie, Chen Yujing, Zhang Zhen, Wen Yan, Jia Yumeng, Zhang Feng

Abstract excerpt

OBJECTIVES: The role of neurological proteins in the development of bipolar disorder (BD) and schizophrenia (SCZ) remains elusive now. The current study aims to explore the potential genetic correlations of plasma neurological proteins with BD and SCZ. METHODS: By using the latest genome-wide association study (GWAS) summary data of BD and SCZ (including 41,917 BD cases, 11,260 SCZ cases, and 396,091 controls)...

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PMID: 35343424
DOI: 10.1017/neu.2022.10

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