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Article

Polygenic Scores and Networks of Psychopathology Symptoms.

JAMA psychiatry - 1 Sept 2024

Piazza Giulia G, Allegrini Andrea G, Eley Thalia C, Epskamp Sacha, Fried Eiko, Isvoranu Adela-Maria, Roiser Jonathan P, Pingault Jean-Baptiste

Abstract excerpt

Importance: Studies on polygenic risk for psychiatric traits commonly use a disorder-level approach to phenotyping, implicitly considering disorders as homogeneous constructs; however, symptom heterogeneity is ubiquitous, with many possible combinations of symptoms falling under the same disorder umbrella. Focusing on individual symptoms may shed light on the role of polygenic risk in psychopathology. Objective:...

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Identifiers

PMID: 38865107
DOI: 10.1001/jamapsychiatry.2024.1403
PMCID: PMC11170456

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