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Article

Glycan shielding and epitope reorganization drive sotrovimab resistance in SARS-CoV-2 Omicron variants.

Archives of biochemistry and biophysics - 1 Aug 2026

Kumar Ankit, Yadav Amar Jeet, Tripathi Timir, Padhi Aditya K

Abstract excerpt

The rapid antigenic evolution of the SARS-CoV-2 spike protein has progressively eroded the efficacy of therapeutic monoclonal antibodies, including sotrovimab. Omicron BA.1 and BA.2 variants exhibit markedly reduced neutralization potency; however, the molecular and energetic mechanisms underlying this resistance, particularly the contribution of glycan-mediated epitope reorganization, remain insufficiently...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42128042
DOI: 10.1016/j.abb.2026.110861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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