Article

Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through multiple mechanisms

2024-01-30

Abstract excerpt

<h4>SUMMARY</h4> Selective pressures have given rise to a number of SARS-CoV-2 variants during the prolonged course of the COVID-19 pandemic. Recently evolved variants differ from ancestors in additional glycosylation within the spike protein receptor-binding domain (RBD). Details of how the acquisition of glycosylation impacts viral fitness and human adaptation are not clearly understood. Here, we dissected the...

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Literature Corpus work: 2a305de6-7fe9-56d0-8124-e6b1618abda3
DOI: 10.1101/2024.01.29.577677

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