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Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity

12 Jun 2024

Abstract excerpt

Selective pressures have given rise to a number of SARS-CoV-2 variants during the prolonged course of the COVID-19 pandemic. Recently evolved variants differ from ancestors in additional glycosylation within the spike protein receptor-binding domain (RBD). Details of how the acquisition of glycosylation impacts viral fitness and human adaptation are not clearly understood. Here, we dissected the role of...

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PMID: 39071099
DOI: 10.1093/nsr/nwae206

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