Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CRISPRi screen of long non-coding RNAs identifies LINC03045 regulating glioblastoma invasion

10 Jun 2024

Abstract excerpt

INTRODUCTION: Glioblastoma (GBM) invasion studies have focused on coding genes, while few studies evaluate long non-coding RNAs (lncRNAs), transcripts without protein-coding potential, for role in GBM invasion. We leveraged CRISPR-interference (CRISPRi) to evaluate invasive function of GBM-associated lncRNAs in an unbiased functional screen, characterizing and exploring the mechanism of identified candidates....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Glioma Diagnosis and Treatment
Share to RNA regulation and disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38857306
DOI: 10.1371/journal.pgen.1011314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CRISPRi screen of long non-coding RNAs identifies LINC03045 regulating glioblastoma invasionPMID 38857306Read ↗

Exploring the Roles of lncRNAs in GBM Pathophysiology and Their Therapeutic Potential.Semantic proximity Read ↗

Applications of CRISPR-Cas9 Technology to Genome Editing in Glioblastoma Multiforme.Semantic proximity Read ↗

Identification of a Druggable Pathway Controlling Glioblastoma InvasivenessSemantic proximity Read ↗

The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation.Semantic proximity Read ↗

CRISPR Screening of E3 Ubiquitin Ligases Reveals Ring Finger Protein 185 as a Novel Tumor Suppressor in Glioblastoma Repressed by Promoter Hypermethylation and miR-587Semantic proximity Read ↗

Targeting the LINC00324/miR-16-5p/SEPT2 Signaling Cascade is Effective to Reverse Malignant Phenotypes in Glioblastoma.Semantic proximity Read ↗

Unlocking Glioblastoma Vulnerabilities with CRISPR-Based Genetic ScreeningSemantic proximity Read ↗

LINC00152 Promotes Invasion through a 3'-Hairpin Structure and Associates with Prognosis in Glioblastoma.Semantic proximity Read ↗

SLFN11 Negatively Regulates Noncanonical NFκB Signaling to Promote Glioblastoma ProgressionSemantic proximity Read ↗

Unlocking glioblastoma vulnerabilities with CRISPR-based genetic screeningSemantic proximity Read ↗

Gain-of-function mutant p53 regulates long-noncoding RNA LINC00643 to modulate HIF1α in glioblastomaSemantic proximity Read ↗

Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.