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CRISPR Screening of E3 Ubiquitin Ligases Reveals Ring Finger Protein 185 as a Novel Tumor Suppressor in Glioblastoma Repressed by Promoter Hypermethylation and miR-587

2021-09-28

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor. E3 ligases play important functions in glioma pathogenesis. CRISPR system offers a powerful platform for genome manipulation, while the screen of E3 ligases in GBM still remains to be explored. Here, we first constructed an E3 ligase small guide RNA (sgRNAs) library for glioma cells growth screening. Aft...

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Literature Corpus work: 4a0cbda2-66a7-574d-a339-1fab0ff60c05
DOI: 10.21203/rs.3.rs-902105/v1

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CRISPR Screening of E3 Ubiquitin Ligases Reveals Ring Finger Protein 185 as a Novel Tumor Suppressor in Glioblastoma Repressed by Promoter Hypermethylation and miR-587DOI 10.21203/rs.3.rs-902105/v1Read

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