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Article

Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas.

Cell reports - 19 Oct 2021

Isaev Keren, Jiang Lingyan, Wu Shuai, Lee Christian A, Watters Valérie, Fort Victoire, Tsai Ricky, Coutinho Fiona J, Hussein Samer M I, Zhang Jie, Wu Jinsong, Dirks Peter B, Schramek Daniel, Reimand Jüri

Abstract excerpt

Long non-coding RNAs (lncRNAs) are increasingly recognized as functional units in cancer and powerful biomarkers; however, most remain uncharacterized. Here, we analyze 5,592 prognostic lncRNAs in 9,446 cancers of 30 types using machine learning. We identify 166 lncRNAs whose expression correlates with survival and improves the accuracy of common clinical variables, molecular features, and cancer subtypes....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34686327
DOI: 10.1016/j.celrep.2021.109873

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