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Article

Pharmacogenetic analysis of structural variation in the 1000 genomes project using whole genome sequences.

Scientific reports - 1 Oct 2024

Sherman Carissa A, Claw Katrina G, Lee Seung-Been

Abstract excerpt

While significant strides have been made in understanding pharmacogenetics (PGx) and gene-drug interactions, there remains limited characterization of population-level PGx variation. This study aims to comprehensively profile global star alleles (haplotype patterns) and phenotype frequencies in 58 pharmacogenes associated with drug absorption, distribution, metabolism, and excretion. PyPGx, a star-allele calling...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 39354004
DOI: 10.1038/s41598-024-73748-3
PMCID: PMC11445439

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