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Article

Reproducible disease phenotyping at scale: Example of coronary artery disease in UK Biobank.

PloS one - 1 Jan 2022

Patel Riyaz S, Denaxas Spiros, Howe Laurence J, Eggo Rosalind M, Shah Anoop D, Allen Naomi E, Danesh John, Hingorani Aroon, Sudlow Cathie, Hemingway Harry

Abstract excerpt

IMPORTANCE: A lack of internationally agreed standards for combining available data sources at scale risks inconsistent disease phenotyping limiting research reproducibility. OBJECTIVE: To develop and then evaluate if a rules-based algorithm can identify coronary artery disease (CAD) sub-phenotypes using electronic health records (EHR) and questionnaire data from UK Biobank (UKB). DESIGN: Case-control and cohort...

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Identifiers

PMID: 35381005
DOI: 10.1371/journal.pone.0264828
PMCID: PMC8982857

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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