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Article

Progressive changes in synaptic inputs to motoneurons in adult sacral spinal cord of a mouse model of amyotrophic lateral sclerosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Dec 2009

Jiang Mingchen, Schuster Jenna E, Fu Ronggen, Siddique Teepu, Heckman C J

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of motoneurons. One potential mechanism is excitotoxicity. We studied the behaviors of spinal neurons using an in vitro preparation of the sacral cord from the G93A SOD1 mouse model of ALS. Measurements were conducted at presymptomatic [approximately postnatal day 50 (approximately P50)], early (approximately P90), and late (>P120)...

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Identifiers

PMID: 19955354
DOI: 10.1523/JNEUROSCI.0574-09.2009
PMCID: PMC3000669

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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