Article

Synaptic imbalance and increased inhibition impair motor function in SMA

2024-09-01

Abstract excerpt

<h4>ABSTRACT</h4> Movement is executed through the balanced action of excitatory and inhibitory neurotransmission in motor circuits of the spinal cord. Short-term perturbations in one of the two types of transmission are counteracted by homeostatic changes of the opposing type. Prolonged failure to balance excitatory and inhibitory drive results in dysfunction at the single neuron, as well as neuronal network lev...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: af4ec026-70d1-563e-8fd4-2230f4e0f12b
DOI: 10.1101/2024.08.30.610545

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Synaptic imbalance and increased inhibition impair motor function in SMADOI 10.1101/2024.08.30.610545Read

Dysfunction of proprioceptive sensory synapses is a pathogenic event and therapeutic target in mice and humans with spinal muscular atrophySemantic proximity Read

Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy.Semantic proximity Read

Motor Neuron Rescue in Spinal Muscular Atrophy Mice Demonstrates That Sensory-Motor Defects Are a Consequence, Not a Cause, of Motor Neuron DysfunctionSemantic proximity Read

At the "junction" of spinal muscular atrophy pathogenesis: the role of neuromuscular junction dysfunction in SMA disease progression.Semantic proximity Read

The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophySemantic proximity Read

Cerebellar pathology contributes to neurodevelopmental deficits in spinal muscular atrophySemantic proximity Read

Motor pool selectivity of neuromuscular degeneration in type I spinal muscular atrophy is conserved between human and mouseSemantic proximity Read

A critical smn threshold in mice dictates onset of an intermediate spinal muscular atrophy phenotype associated with a distinct neuromuscular junction pathology.Semantic proximity Read

Astrocytes influence the severity of spinal muscular atrophy.Semantic proximity Read

Cerebellar pathology contributes to neurodevelopmental deficits in spinal muscular atrophySemantic proximity Read

SMN deficiency induces an early non-atrophic myopathy with alterations in the contractile and excitatory coupling machinery of skeletal myofibers in the SMNΔ7 mouse model of spinal muscular atrophySemantic proximity Read

Diminished motor neuron activity driven by abnormal astrocytic GLAST glutamate transporter activity in spinal muscular atrophy is not fully restored after lentiviral SMN deliverySemantic proximity Read