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Article

Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS

2023-03-07

Abstract excerpt

<title>Abstract</title> <p>Loss of connectivity between spinal V1 inhibitory interneurons and motor neurons is found early in disease in the SOD1G93A mice. Such changes in premotor inputs can contribute to homeostatic imbalance of vulnerable motor neurons. Here, we show, for the first time, that stabilization of V1 synapses by overexpression of a presynaptic organizer, increases motor neuron survival and ameliora...

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Literature Corpus work
e34790b2-8adc-593b-9dbe-f7af80083ea9
DOI
10.21203/rs.3.rs-2613071/v1
Open publication

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Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALSDOI 10.21203/rs.3.rs-2613071/v1
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