Article

Stabilization of V1 interneuron-motor neuron connectivity ameliorates motor phenotype in a mouse model of ALS

2022-12-15

Abstract excerpt

Loss of connectivity between spinal V1 inhibitory inter-neurons and motor neurons is found early in disease in the SOD1 G93A ALS mice. Such changes in premotor inputs can contribute to homeostatic imbalance of vulnerable motor neurons. Here, we show, for the first time, that stabilization of V1 synapses by overexpression of the Extended Synap-totagmin 1 presynaptic organizer increases motor neuron survival and am...

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Literature Corpus work: 90fb54c8-a7d4-59d9-a495-57e80177d0af
DOI: 10.1101/2022.12.15.520568

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