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Differential activation of rhodopsin triggers distinct endocytic trafficking and recycling in vivo via differential phosphorylation.

PloS one - 1 Jan 2024

Ferng Darwin, Sun Wesley, Shieh Bih-Hwa

Abstract excerpt

Activated GPCRs are phosphorylated and internalized mostly via clathrin-mediated endocytosis (CME), which are then sorted for recycling or degradation. We investigated how differential activation of the same GPCR affects its endocytic trafficking in vivo using rhodopsin as a model in pupal photoreceptors of flies expressing mCherry-tagged rhodopsin 1 (Rh1-mC) or GFP-tagged arrestin 1 (Arr1-GFP). Upon blue light...

Topics

Animals
Clathrin
Drosophila melanogaster
Endocytosis
Light
Mutation
Phosphorylation
Photoreceptor Cells, Invertebrate
Protein Transport
Rhodopsin
Drosophila Proteins

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Identifiers

PMID: 38848405
DOI: 10.1371/journal.pone.0303882
PMCID: PMC11161057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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