Article
BRAF-V600E mutations in plasma and peripheral blood mononuclear cells correlate with prognosis of pediatric Langerhans cell histiocytosis treated with first-line therapy.
Pediatric blood & cancer - 1 Sept 2024
Wang Chan-Juan, Zhu Ting, Zhao Chen-Zi, Cui Hua, Wang Dong, Zhao Zi-Jing, Huang Xiao-Tong, Li Hua-Lin, Liu Fei-Fei, Zhang Rui, Li Zhi-Gang, Cui Lei
Abstract excerpt
BACKGROUND: The clinical relevance of BRAF-V600E alleles in peripheral blood mononuclear cells (PBMCs) and the prognostic impact of the mutants in cell-free (cf) and PBMC DNAs of Langerhans cell histiocytosis (LCH) have not been fully clarified in pediatric LCH. METHODS: We retrospectively determined the levels of BRAF-V600E mutation in paired plasma and PBMC samples at the time of diagnosis of LCH. Subsequently,...
Topics
- Humans
- Histiocytosis, Langerhans-Cell
- Proto-Oncogene Proteins B-raf
- Male
- Female
- Retrospective Studies
- Child
- Child, Preschool
- Prognosis
- Leukocytes, Mononuclear