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Article

Left corticospinal tract could be a biomarker to identify the dual prodromal LRRK2/GBA mutated Parkinson's disease.

CNS neuroscience & therapeutics - 1 Jun 2024

Lin Fabin, Ruan Xinlin, Zou Xinyang, Weng Huidan, Zeng Yuqi, Zheng Jiayi, Ye Qinyong, Meng Fangang, Chen Xiaochun, Cai Guoen

Abstract excerpt

INTRODUCTION: Prodromal Parkinson's disease (PD) carriers of dual leucine-rich repeat kinase 2 (LRRK2) and glucosylceramidase β (GBA) variants are rare, and their biomarkers are less well developed. OBJECTIVE: This study aimed to investigate the biomarkers for diagnosing the prodromal phase of LRRK2-GBA-PD (LRRK2-GBA-prodromal). METHODS: We assessed the clinical and whole-brain white matter microstructural...

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Identifiers

PMID: 38837664
DOI: 10.1111/cns.14728
PMCID: PMC11150277

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