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Article

Sororin is an evolutionary conserved antagonist of WAPL.

Nature communications - 3 Jun 2024

Prusén Mota Ignacio, Galova Marta, Schleiffer Alexander, Nguyen Tan-Trung, Kovacikova Ines, Farias Saad Carolina, Litos Gabriele, Nishiyama Tomoko, Gregan Juraj, Peters Jan-Michael, Schlögelhofer Peter

Abstract excerpt

Cohesin mediates sister chromatid cohesion to enable chromosome segregation and DNA damage repair. To perform these functions, cohesin needs to be protected from WAPL, which otherwise releases cohesin from DNA. It has been proposed that cohesin is protected from WAPL by SORORIN. However, in vivo evidence for this antagonism is missing and SORORIN is only known to exist in vertebrates and insects. It is therefore...

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Identifiers

PMID: 38830897
DOI: 10.1038/s41467-024-49178-0
PMCID: PMC11148194

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