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Article

UCHL3 induces radiation resistance and acquisition of mesenchymal phenotypes by deubiquitinating POLD4 in glioma stem cells.

Cellular and molecular life sciences : CMLS - 3 Jun 2024

Fan Ligang, You Hongtao, Jiang Xiao, Niu Yixuan, Chen Zhengxin, Wang Huibo, Xu Yuan, Zhou Peng, Wei Li, Jiang Tianwei, Deng Danni, Xue Lian, Peng Ya, Xing Wei, Shao Naiyuan

Abstract excerpt

BACKGROUND: The high degree of intratumoral genomic heterogeneity is a major obstacle for glioblastoma (GBM) tumors, one of the most lethal human malignancies, and is thought to influence conventional therapeutic outcomes negatively. The proneural-to-mesenchymal transition (PMT) of glioma stem cells (GSCs) confers resistance to radiation therapy in glioblastoma patients. POLD4 is associated with cancer...

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Identifiers

PMID: 38829550
DOI: 10.1007/s00018-024-05265-5
PMCID: PMC11149539

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