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Article

Centromere protein U mediates the ubiquitination and degradation of RPS3 to facilitate temozolomide resistance in glioblastoma

22 Feb 2025

Abstract excerpt

AIMS: Temozolomide (TMZ) is the first-line chemotherapeutic agent for glioblastoma (GBM) therapy; however, resistance to TMZ remains a major obstacle in GBM treatment. The aim of this study is to elucidate the mechanisms underlying TMZ resistance and explore how to enhance the sensitivity of GBM to TMZ. METHODS: GBM organoids were generated from patient samples, and organoid-based TMZ sensitivity testing was...

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PMID: 40023134
DOI: 10.1016/j.drup.2025.101214

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