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UCHL3: a crucial deubiquitinase in DNA damage repair and tumor progression

21 Jul 2025

Abstract excerpt

Ubiquitin carboxyl terminal hydrolase L3 (UCHL3) is a deubiquitinase belonging to UCH protease family. Previous studies have demonstrated that abnormal expression of UCHL3 is correlated with the development of human diseases, especially in tumors. Notably, UCHL3 exhibits contradictory biological functions across different cancer types. Initial studies identified UCHL3 as a tumor suppressor in prostate cancer....

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PMID: 40691601
DOI: 10.1186/s12935-025-03884-x

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