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USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells

7 Apr 2019

Abstract excerpt

The mesenchymal (MES) subtype of glioblastoma (GBM) stem cells (GSCs) represents a subpopulation of cancer cells that are notorious for their highly aggressive nature and resistance to conventional therapy. Aldehyde dehydrogenase 1A3 (ALDH1A3) has been recently suggested as a key determinant for the maintenance of MES features of GSCs. However, the mechanisms underpinning aberrant ALDH1A3 expression remain...

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PMID: 30958800
DOI: 10.1172/jci126414

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