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Article

Raman-based machine-learning platform reveals unique metabolic differences between IDHmut and IDHwt glioma.

Neuro-oncology - 4 Nov 2024

Lita Adrian, Sjöberg Joel, Păcioianu David, Siminea Nicoleta, Celiku Orieta, Dowdy Tyrone, Păun Andrei, Gilbert Mark R, Noushmehr Houtan, Petre Ion, Larion Mioara

Abstract excerpt

BACKGROUND: Formalin-fixed, paraffin-embedded (FFPE) tissue slides are routinely used in cancer diagnosis, clinical decision-making, and stored in biobanks, but their utilization in Raman spectroscopy-based studies has been limited due to the background coming from embedding media. METHODS: Spontaneous Raman spectroscopy was used for molecular fingerprinting of FFPE tissue from 46 patient samples with known...

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Identifiers

PMID: 38828478
DOI: 10.1093/neuonc/noae101
PMCID: PMC11534323

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