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Article

Optical Analysis of Glioma: Fourier-Transform Infrared Spectroscopy Reveals the IDH1 Mutation Status.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2018

Uckermann Ortrud, Juratli Tareq A, Galli Roberta, Conde Marina, Wiedemuth Ralf, Krex Dietmar, Geiger Kathrin, Temme Achim, Schackert Gabriele, Koch Edmund, Steiner Gerald, Kirsch Matthias

Abstract excerpt

Purpose: Somatic mutations in the human cytosolic isocitrate dehydrogenase 1 (IDH1) gene cause profound changes in cell metabolism and are a common feature of gliomas with unprecedented predictive and prognostic impact. Fourier-transform infrared (FT-IR) spectroscopy addresses the molecular composition of cells and tissue and was investigated to deduct the IDH1 mutation status.Experimental Design: We tested the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29259030
DOI: 10.1158/1078-0432.CCR-17-1795

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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