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Article

IDH1 mutation in human glioma induces chemical alterations that are amenable to optical Raman spectroscopy.

Journal of neuro-oncology - 1 Sept 2018

Uckermann Ortrud, Yao Wenmin, Juratli Tareq A, Galli Roberta, Leipnitz Elke, Meinhardt Matthias, Koch Edmund, Schackert Gabriele, Steiner Gerald, Kirsch Matthias

Abstract excerpt

INTRODUCTION: Mutations in the isocytrate dehydrogenase 1 (IDH1) gene are early genetic events in glioma pathogenesis and cause profound metabolic changes. Because this genotype is found in virtually every tumor cell, therapies targeting mutant IDH1 protein are being developed. The intraoperative administration of those therapies would require fast technologies for the determination of IDH1 genotype. As of today,...

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Identifiers

PMID: 29761368
DOI: 10.1007/s11060-018-2883-8

Genes

IDH1

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